Microfluidic single-cell technologies: precision printing for personalized medicine

Using innovative methods of microfluidics and single cell technologies, the Fraunhofer Institute for Microengineering and Microsystems IMM has developed a pioneering approach to precisely print organ structures. Microfluidic structures make it possible to eject cells in a targeted manner and position them in high resolution. This technology offers new possibilities for personalized medical applications, including drug tests on organ cultures and, in the long term, even skin transplants and printed tissue. 

The team at Fraunhofer IMM has developed special microfluidic chips in the clean room that specifically trap human cells in tiny channels. These “cell traps” have a specific geometry that only captures individual cells, while other cells flow to the next free position. The TrapJet system works like an inkjet printer, using a heating bladder to deposit the cells in precise droplets. Different cell types are printed separately, which ensures precise control and a high viability rate of the printed cells. 

In order to fully exploit the potential of microfluidics for medicine, the Fraunhofer IMM, together with the “Clinical Health Technologies” department of the Fraunhofer IPA in Mannheim, will establish a center of excellence for single-cell technologies. Here, the researchers will continue to pool their expertise and bring the developments to series maturity. 

COMPAMED-tradefair.com; Source: Fraunhofer Institute for Microengineering and Microsystems IMM