FDmiX platform increases serial production of high-quality nanoparticles

Nucleic acid-based medications such as mRNA vaccines are revolutionizing medicine. However, in order to be effective, these active ingredients must be transported into the body's cells in a targeted manner. This is where nanoparticles come into play, acting as a protective shell and delivering the active ingredient safely to its destination.

The production of nanoparticles in industrial quantities, however, poses a major challenge. Conventional processes often lead to inhomogeneous particles with insufficient stability. This can impair the effectiveness of the active ingredients and even lead to undesirable side effects.

The FDmiX platform solves these problems with an innovative mixing technology that ensures consistently high mixing quality from laboratory scale to series production. At the heart of the technology is an OsciJet nozzle, which ensures a high-frequency oscillation of the flow. This ensures that the active ingredients and carrier materials are optimally mixed, resulting in homogeneous nanoparticles with a defined size and stability.

• Highest particle quality: Significantly smaller and more homogeneous nanoparticles compared to conventional processes
• Improved substance efficiency: Lower dispersion and high encapsulation efficiency for optimum substance yield
• Scalability: Flexible system for the production of nanoparticles in various sizes
• Wide range of applications: Wide range of applications in medicine, pharmacy and cosmetics

The FDmiX nanoparticles are already being used in various medical applications, including the stable encapsulation of mRNA for effective immunization, as a coating for cardiac catheters to prevent vascular deposits in cardiology, for targeted drug delivery to combat cancer cells in tumor therapy or during the treatment of neurodegenerative diseases.

The FDmiX platform marks a paradigm shift in the production of nanoparticles in the pharmaceutical, chemical and biotech industries and opens up new possibilities for the development of innovative therapies in medicine. The technology enables the production of nanoparticles of unprecedented quality and stability, which holds enormous potential for the future of medicine, especially for difficult-to-treat diseases.

COMPAMED-tradefair.com; Source: Fraunhofer Institute for Production Systems and Design Technology IPK